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The participants were all assessed to be at a high risk of cardiovascular disease and all had high triglyceride levels. They were also taking Statins to reduce cholesterol. Each of them were given fish oil of either 2 gr or 4 gr daily or a placebo. The results showed that those taking the 4 grams a day of EPA fish oil saw an average reduction of triglyceride levels of 22 percent/had the biggest reduction of triglyceride levels.
These results came from the ANCHOR trial, which was a study sponsored by Amarin, the company which is developing AMR101 a concentrated and purified Omega 3 EPA fish oil.The Anchor trial involved individuals with an average age of 61 and an average BMI of 33. Around 73 percent had diabetes, 30 percent were on a "high" efficacy statin regimen, 68 percent were on a "medium" efficacy regimen and 7 percent were on a "low" efficacy regimen.
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Professor Ballantyne also suggested at the annual scientific sessions of the American Heart Association that he thinks the chances of fish oil working are greater than other treatments but acknowledged that no one has carried out a trial specifically on patients with high triglyceride levels.
Amarin is soon to start the clinical end point trial REDUCE IT (Reduction of Cardiovascular Events with EPA Intervention Trial) which will last for about 6 years. This trial will involve approximately 8,000 peopl with elevated triglyceride levels. The results of this study are expected to, will no doubt offer a clearer insight into the benefits of EPA fish oil for lessening the risk of cardiac events.
Another study conducted previously known as the JELIS study (Japan EPA Lipid Intervention Study), involving more than 19,000 individuals some with and some free from heart disease but with high cholesterol levels found that those taking statins along with fish oil had less of a risk of having a major coronary event than those who were only taking Statins with no fish oil. Although the JELIS study didn't focus on individuals with high triglyceride levels, but on those with high cholesterol levels, the results show that fish oil had a beneficial/positive effect on coronary events.
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